On October 4, 2004, Opie and Anthony started broadcasting on XM Satellite Radio, marking the first time that a major radio show made the move to satellite radio.

Opie & Anthony originally started broadcasting on a premium channel (High Voltage ch 202) that required an additional $1.99 monthly fee (XM was $9.99 a month at the time). In April 2005, the O&A virus was released to the rest of the XM Nation when the premium channel was made available to all subscribers and XM's monthly fee was upped to $12.95.

To celebrate their two-year anniversary, O&A are teasing a 'special announcement' that will be made today for XM listeners. While speculation abounds, it is known that XM registered "The Virus" trademark in late August, so a channel name change could very well be in order.

Opie and Anthony are under contract with XM until 2010, and currently simulcast on 24 terrestrial radio stations. According to FMQB, there is mounting pressure to expand their terrestrial show by 1-hour to 10am in order to better suit Arbitron's morning drive ratings system. Currently terrestrial radio stations are losing out on 1/4 of O&A's ratings when lower rated mid-day programming go on the air (WFNY's audience drops in half when JV & Elvis air).